Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992901 | 0.80 | PKM (0.66) | MAPTLMNAKMT2AMEN1SIRT6 | |
| SCHEMBL6055083 | 0.76 | VCAM1 (0.69) | MAPTLMNAKMT2AMEN1SIRT6 | |
| SCHEMBL3147203 | 0.75 | SIRT6 (0.83) | MAPTSIRT6L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL5951699 | 0.74 | KMT2A (0.71) | MAPTLMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL27788104 | 0.73 | CHRM2 (0.50) | TDP1SMN1; SMN2CYP2C19HTR6 | |
| SCHEMBL1911607 | 0.72 | MAPT (0.71) | MAPTLMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL27605812 | 0.71 | PARG (0.40) | MAPTLMNAKMT2AMEN1TDP1 | |
| SCHEMBL1847175 | 0.69 | SIRT6 (1.00) | MAPTSIRT6L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL27845916 | 0.68 | SMN1; SMN2 (0.40) | MAPTKMT2AMEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27951598 | 0.68 | CHRM2 (0.36) | MAPTKMT2AMEN1SIRT6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471317-B | Aminopyridine derivatives for treating tumors and inflammatory diseases | MERCK PATENT GMBH | 2014-02-26 | — | — | CN | disclosed |
| CN-102471317-A | Aminopyridine derivatives for treating tumors and inflammatory diseases | MERCK PATENT GMBH | 2012-05-23 | — | — | CN | disclosed |