Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27853895 | 0.85 | MAPT (0.48) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28792687 | 0.83 | MEN1 (0.46) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL27605945 | 0.83 | LMNA (0.47) | MEN1KMT2AALDH1A1LMNARXFP1 | |
| SCHEMBL13206126 | 0.81 | ALDH1A1 (0.42) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28031060 | 0.79 | GPBAR1 (0.40) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8302020 | 0.79 | DTYMK (0.48) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5068050 | 0.76 | KAT6A (0.46) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL27605852 | 0.76 | LMNA (0.45) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL27640385 | 0.76 | HTT (0.53) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4137682 | 0.75 | HPGD (0.51) | TSHRMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471284-A | Dihydropyrimidone amides as P2X7 modulators | HOFFMANN LA ROCHE | 2012-05-23 | — | — | CN | disclosed |