Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | WRN | Q14191 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27997782 | 0.84 | ALDH1A1 (0.41) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL4450857 | 0.81 | NAAA (0.41) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL974718 | 0.81 | HTT (0.50) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL8402125 | 0.80 | NAAA (0.38) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL12112110 | 0.80 | NAAA (0.38) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| Ammonia Solution, Strong SCHEMBL4621612 | 0.79 | NAAA (0.40) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL28871728 | 0.78 | NAAA (0.36) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL15281013 | 0.78 | LMNA (0.45) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL14472846 | 0.78 | NAAA (0.43) | NAAAALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL722286 | 0.78 | NAAA (0.43) | NAAAALDH1A1CYP1A2HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471293-B | Oxazine derivatives and their use as BACE inhibitors for the treatment of neurological disorders | NOVARTIS AG (CH) | 2014-10-01 | — | — | CN | disclosed |
| CN-102666507-B | Oxazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2014-09-17 | — | — | CN | disclosed |
| CN-103596569-A | BACE-2 inhibitors for the treatment of metabolic disorders | NOVARTIS AG | 2014-02-19 | — | — | CN | disclosed |
| CN-103429588-A | Crystalline oxazine derivative and its use as bace inhibitor | NOVARTIS AG | 2013-12-04 | — | — | CN | disclosed |
| CN-103429589-A | Oxazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2013-12-04 | — | — | CN | disclosed |
| CN-103403001-A | Novel heterocyclic derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |
| CN-102666507-A | Oxazine derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2012-09-12 | — | — | CN | disclosed |
| CN-102471293-A | Oxazine derivatives and their use as BACE inhibitors for the treatment of neurological disorders | NOVARTIS AG | 2012-05-23 | — | — | CN | disclosed |