Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Uracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL151239 | 0.88 | — | — | |
| Uracil SCHEMBL5182388 | 0.85 | — | — | |
| Uracil SCHEMBL27271010 | 0.85 | — | — | |
| Uracil SCHEMBL28745089 | 0.85 | — | — | |
| Uracil SCHEMBL5125135 | 0.80 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1 | |
| Uracil SCHEMBL15456754 | 0.79 | KDM4E (0.34) | ALDH1A1L3MBTL1 | |
| Uracil SCHEMBL6557359 | 0.77 | KDM4E (0.41) | ALDH1A1 | |
| Uracil SCHEMBL28028641 | 0.76 | HSP90AA1 (0.32) | — | |
| Biphenyl SCHEMBL27705553 | 0.76 | AURKA (0.44) | ALDH1A1 | |
| Uracil SCHEMBL28281876 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102464667-A | Five-membered heterocyclic pyrimidine compounds, preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2012-05-23 | — | — | CN | disclosed |