Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309001 | 1.00 | TPH1 (0.65) | TPH1 | |
| SCHEMBL869851 | 0.86 | TPH1 (0.56) | TPH1 | |
| SCHEMBL20274801 | 0.79 | TPH1 (0.70) | TPH1 | |
| SCHEMBL307395 | 0.79 | TPH1 (1.00) | TPH1 | |
| SCHEMBL309002 | 0.79 | TPH1 (1.00) | TPH1 | |
| SCHEMBL2733443 | 0.79 | TPH1 (0.59) | TPH1 | |
| SCHEMBL24424989 | 0.76 | SLC7A5 (0.62) | TPH1 | |
| SCHEMBL13509497 | 0.76 | SLC7A5 (0.62) | TPH1 | |
| SCHEMBL1873078 | 0.75 | TPH1 (0.67) | TPH1 | |
| Hydrochloric Acid SCHEMBL7307861 | 0.75 | SLC7A5 (0.61) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753168-A | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease | LEXICON PHARMACEUTICALS INC | 2012-10-24 | — | — | CN | disclosed |
| CN-102711757-A | Methods and assays for treating irritable bowel syndrome | LEXICON PHARMACEUTICALS INC | 2012-10-03 | — | — | CN | disclosed |
| CN-102711749-A | Tryptophan hydroxylase inhibitors for the treatment of cancer | LEXICON PHARMACEUTICALS INC | 2012-10-03 | — | — | CN | disclosed |