Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789114 | 0.90 | NOTUM (0.52) | POLBNOTUMLMNASLC6A4KDM4E | |
| SCHEMBL15721520 | 0.83 | NOTUM (0.50) | POLBNOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL27876294 | 0.80 | TP53 (0.53) | POLBLMNASLC6A4MAPTTP53 | |
| SCHEMBL948848 | 0.79 | ALDH1A1 (0.52) | POLBRXFP1NOTUMLMNAKDM4E | |
| SCHEMBL945154 | 0.76 | NOTUM (0.51) | POLBNOTUMLMNAKDM4EALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27768427 | 0.75 | SIGMAR1 (0.51) | SLC6A4 | |
| SCHEMBL931075 | 0.72 | SIGMAR1 (0.48) | SLC6A4 | |
| SCHEMBL8569157 | 0.72 | NOTUM (0.61) | POLBNOTUMLMNAKDM4EALDH1A1 | |
| SCHEMBL13020232 | 0.72 | NOTUM (0.61) | POLBNOTUMLMNATRIM24KDM4E | |
| SCHEMBL27781919 | 0.71 | ALDH1A1 (0.53) | NOTUMKDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482264-A | 2-carbamoyl-7-piperazinyl-benzofuran derivatives 774 | ASTRAZENECA AB | 2012-05-30 | — | — | CN | disclosed |