Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786014 | 0.95 | P2RX7 (0.41) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| SCHEMBL2790343 | 0.90 | EPHX2 (0.41) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| SCHEMBL2788026 | 0.88 | L3MBTL1 (0.42) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| SCHEMBL2785904 | 0.88 | EPHX2 (0.40) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| SCHEMBL2787720 | 0.87 | EPHX2 (0.41) | EPHX2L3MBTL1PTPN7DUSP3POLB | |
| SCHEMBL13165610 | 0.87 | BDKRB1 (0.47) | P2RX7EPHX2POLB | |
| SCHEMBL2808220 | 0.86 | P2RX7 (0.40) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| SCHEMBL765638 | 0.85 | EPHX2 (0.48) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| SCHEMBL12238932 | 0.85 | L3MBTL1 (0.43) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 | |
| Trifluoroacetic Acid SCHEMBL2789689 | 0.85 | P2RX7 (0.42) | P2RX7EPHX2L3MBTL1PTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |