Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786358 | 0.95 | P2RX7 (0.39) | P2RX7BDKRB1EPHX2POLBFAAH | |
| SCHEMBL2808204 | 0.92 | P2RX7 (0.39) | P2RX7BDKRB1EPHX2POLBALDH1A1 | |
| SCHEMBL13165610 | 0.92 | BDKRB1 (0.47) | P2RX7BDKRB1EPHX2POLB | |
| SCHEMBL2788425 | 0.91 | EPHX2 (0.41) | P2RX7BDKRB1EPHX2POLBFAAH | |
| SCHEMBL2809672 | 0.91 | P2RX7 (0.37) | P2RX7BDKRB1EPHX2POLBFAAH | |
| SCHEMBL2810276 | 0.91 | P2RX7 (0.38) | P2RX7BDKRB1EPHX2POLBALDH1A1 | |
| SCHEMBL2788200 | 0.90 | BDKRB1 (0.38) | P2RX7BDKRB1EPHX2POLBFAAH | |
| SCHEMBL2812521 | 0.90 | BDKRB1 (0.38) | P2RX7BDKRB1EPHX2POLBFAAH | |
| SCHEMBL2812285 | 0.88 | POLB (0.36) | P2RX7BDKRB1EPHX2POLBALDH1A1 | |
| SCHEMBL2787448 | 0.88 | L3MBTL1 (0.36) | P2RX7BDKRB1EPHX2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |