Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 9/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235686 | 0.88 | ICMT (0.57) | ICMTHTR2AHTR2CERBB2NTSR1 | |
| Methylamine SCHEMBL27990030 | 0.85 | ICMT (0.56) | ICMTHTR2AHTR2CERBB2NTSR1 | |
| SCHEMBL27879582 | 0.81 | ERBB2 (0.45) | ICMTERBB2NTSR1HDAC8HDAC6 | |
| SCHEMBL11893595 | 0.78 | HTR2A (0.54) | ICMTHTR2AHTR2CNTSR1 | |
| SCHEMBL25146817 | 0.75 | KMT2A (0.54) | HTR2AHTR2CNTSR1HDAC3HDAC1 | |
| SCHEMBL29369688 | 0.73 | CDK4 (0.55) | ICMTHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL14512683 | 0.73 | SCN9A (0.40) | ICMTHTR2AHTR2CERBB2SCN9A | |
| SCHEMBL28412665 | 0.73 | PLA2G4A (0.51) | — | |
| SCHEMBL3867537 | 0.71 | HTR6 (0.52) | ERBB2NTSR1HDAC3HDAC1HDAC2 | |
| SCHEMBL11896273 | 0.70 | ERBB2 (0.45) | ICMTHTR2AHTR2CERBB2NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574787-B | Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity | UNIV SINGAPORE | 2014-12-31 | — | — | CN | disclosed |
| CN-102574787-A | Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity | UNIV SINGAPORE | 2012-07-11 | — | — | CN | disclosed |