Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.86 |
| ▸ | GRM6 | O15303 | 2/20 | 0.86 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.86 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.86 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.86 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.86 |
| ▸ | GSR | P00390 | 1/20 | 0.86 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.86 |
| ▸ | GRM5 | P41594 | 1/20 | 0.86 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.86 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.86 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.86 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.86 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.86 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.86 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.86 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.86 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.86 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL15797537 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL28509459 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL28330083 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL184512 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL2803034 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL184513 | 1.00 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL787885 | 0.98 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL787628 | 0.98 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL20528822 | 0.98 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL381869 | 0.98 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102827016-B | Preparation of novel green chelating agent glutamic diacetate tetracetic acid metal salt | SHIJIAZHUANG JACK CHEMICAL CO LTD | 2015-04-01 | — | — | CN | disclosed |
| CN-102827016-B | Preparation of novel green chelating agent glutamic diacetate tetracetic acid metal salt | SHIJIAZHUANG JACK CHEMICAL CO LTD | 2015-04-01 | — | — | CN | disclosed |
| CN-102827016-A | Preparation of novel green chelating agent glutamic diacetate tetracetic acid metal salt | SHIJIAZHUANG JACK CHEMICAL CO LTD | 2012-12-19 | — | — | CN | disclosed |
| CN-102827016-A | Preparation of novel green chelating agent glutamic diacetate tetracetic acid metal salt | SHIJIAZHUANG JACK CHEMICAL CO LTD | 2012-12-19 | — | — | CN | disclosed |