Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.35 |
| ▸ | PPARA | Q07869 | 7/20 | 0.35 |
| ▸ | PPARD | Q03181 | 7/20 | 0.35 |
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884222 | 0.89 | PPARG (0.37) | PPARGPPARAPPARDACLYPSEN1 | |
| SCHEMBL28797216 | 0.88 | PHGDH (0.41) | PPARGPPARAPPARDACLYPSEN1 | |
| SCHEMBL27884309 | 0.86 | PPARG (0.32) | PPARGPPARAPPARDACLYPSEN1 | |
| SCHEMBL27867732 | 0.85 | CCR2 (0.45) | PPARGPPARAPPARDACLYCCR2 | |
| SCHEMBL12096673 | 0.85 | PPARG (0.49) | PPARGPPARAPPARDACLYPSEN1 | |
| SCHEMBL27884203 | 0.82 | PPARG (0.34) | PPARGPPARAPPARDACLYPLA2G4A | |
| SCHEMBL27867735 | 0.81 | ACLY (0.42) | PPARGPPARAPPARDACLYPLA2G4A | |
| SCHEMBL27884472 | 0.81 | PHGDH (0.39) | PPARGPPARAPPARDACLYPLA2G4A | |
| SCHEMBL27884365 | 0.80 | ACLY (0.40) | PPARGPPARAPPARDACLYPLA2G4A | |
| SCHEMBL28800052 | 0.79 | ACLY (0.43) | PPARGPPARAPPARDACLYPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |