Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.37 |
| ▸ | PPARD | Q03181 | 4/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884472 | 0.93 | PHGDH (0.39) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27884365 | 0.92 | ACLY (0.40) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL28800052 | 0.91 | ACLY (0.43) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27884356 | 0.90 | PPARG (0.43) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27867732 | 0.90 | CCR2 (0.45) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27867735 | 0.90 | ACLY (0.42) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27867729 | 0.90 | ACLY (0.38) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27884205 | 0.88 | PPARG (0.35) | PHGDHACLYPPARGPPARAPPARD | |
| SCHEMBL27884317 | 0.86 | ACLY (0.40) | ACLYPPARGPPARAPPARDPLA2G4A | |
| SCHEMBL27884222 | 0.86 | PPARG (0.37) | PHGDHACLYPPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |