Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | CHUK | O15111 | 3/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857300 | 0.86 | LRRK2 (0.47) | LRRK2METROCK1JAK2CHUK | |
| SCHEMBL1887197 | 0.77 | ROCK2 (0.36) | LRRK2METROCK1ROCK2CDC42BPB | |
| SCHEMBL3813831 | 0.75 | MET (0.65) | METROCK1ROCK2GSK3BPRKD3 | |
| SCHEMBL1888240 | 0.72 | CYP3A4 (0.49) | KDRAURKBCSF1RNTRK3FLT1 | |
| SCHEMBL26953278 | 0.72 | SGK1 (0.57) | LRRK2ROCK1ROCK2GSK3BJAK2 | |
| SCHEMBL31735012 | 0.72 | SGK1 (0.57) | LRRK2ROCK1ROCK2GSK3BJAK2 | |
| SCHEMBL857282 | 0.70 | LRRK2 (0.51) | LRRK2GSK3BCDK5CDK8CDK9 | |
| SCHEMBL20086205 | 0.70 | LRRK2 (0.50) | LRRK2GSK3BCDK5DYRK1ACDK8 | |
| SCHEMBL857855 | 0.68 | SIK1 (0.51) | LRRK2CSF1RCDK8FYNMAPK1 | |
| SCHEMBL22988837 | 0.68 | MET (0.41) | METFGFR1KDRAURKBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102695417-A | Compounds and methods for kinase modulation and indications therefor | PLEXXIKON INC | 2012-09-26 | — | — | CN | disclosed |