SCHEMBL27891

SCHEMBL27891

OCCc1ccccc1CO

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APOBEC3G Q9HC16 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
CYP4F2 P78329 2/20 0.47
CYP4A11 Q02928 2/20 0.47
TAAR1 Q96RJ0 1/20 0.41
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
TSHR P16473 2/20 0.39
CYP2A6 P11509 1/20 0.38
PTPN1 P18031 2/20 0.37
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.36
HSPA5 P11021 1/20 0.36
MPO P05164 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
FFAR1 O14842 1/20 0.35
CA2 P00918 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30563551 1.00 APOBEC3G (0.48) APOBEC3GTDP1CYP4F2CYP4A11TAAR1
SCHEMBL31203 0.91 TDP1 (0.55) APOBEC3GTDP1CYP4F2CYP4A11TAAR1
SCHEMBL29534868 0.91 TDP1 (0.55) APOBEC3GTDP1CYP4F2CYP4A11TAAR1
SCHEMBL29366632 0.85 APOBEC3G (0.60) APOBEC3GTDP1CYP4F2CYP4A11TAAR1
SCHEMBL41139 0.85 APOBEC3G (0.60) APOBEC3GTDP1CYP4F2CYP4A11TAAR1
SCHEMBL27292 0.84 CYP4F2 (0.49) APOBEC3GTDP1CYP4F2CYP4A11TAAR1
Tetrahydrofuran SCHEMBL4655531 0.82 CYP4F2 (0.40) APOBEC3GTDP1CYP4F2CYP4A11TSHR
SCHEMBL43837 0.81 TAAR1 (0.62) TDP1TAAR1TSHRHSPA5MPO
SCHEMBL29646276 0.81 TAAR1 (0.62) TDP1TAAR1TSHRHSPA5MPO
Hydrochloric Acid SCHEMBL28375849 0.79 APOBEC3G (0.55) APOBEC3GCYP4F2CYP4A11TAAR1PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113880688-B Synthesis method of diol 温州大学新材料与产业技术研究院 2023-09-08 CN disclosed
CN-113880688-A Method for synthesizing diol 温州大学新材料与产业技术研究院 2022-01-04 CN disclosed
US-11136326-B2 Pyrrolopyrimidine derivatives as TAM inhibitors INCYTE CORPORATION (US) 2021-10-05 US disclosed
US-11136326-B2 Pyrrolopyrimidine derivatives as TAM inhibitors INCYTE CORPORATION (US) 2021-10-05 US disclosed
CN-108610237-B Method for synthesizing o-xylene glycol derivative 复旦大学 2021-07-23 CN disclosed
US-20200392498-A1 POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS SOLSTICE BIOLOGICS LTD (IE) 2020-12-17 US disclosed
US-20200239452-A1 IDO/TDO Inhibitor CANBAS CO., LTD. (JP) 2020-07-30 US disclosed
US-20200181151-A1 PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS INCYTE CORPORATION 2020-06-11 US disclosed
US-20200181151-A1 PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS INCYTE CORPORATION 2020-06-11 US disclosed
EP-2044251-B1 BIODEGRADABLE ALIPHATIC POLYESTER FOR USE IN NONWOVEN WEBS NATUREWORKS LLC (US) 2019-10-02 EP disclosed
US-4213972-A BACTERICIDES ABBOTT LABORATORIES (US) 1980-07-22 US disclosed
US-4213974-A ANTIBACTERIAL ABBOTT LABORATORIES (US) 1980-07-22 US disclosed
US-4188319-A ANTIBIOTICS ABBOTT LABORATORIES (US) 1980-02-12 US disclosed
US-4183920-A ANTIBIOTICS ABBOTT LABORATORIES (US) 1980-01-15 US disclosed
US-4174312-A ACYLATION, HYDROLYSIS, SALT FORMATION, CATALYTIC HYDROGENATION ABBOTT LABORATORIES (US) 1979-11-13 US disclosed
US-4173564-A 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A ABBOTT LABORATORIES (US) 1979-11-06 US disclosed
US-4155902-A ACYLATION, HYDROGENOLYSIS ABBOTT LABORATORIES (US) 1979-05-22 US disclosed
US-4147711-A Ethylenic silicon compounds and thermoplastic elastomers obtained therefrom RHONE-POULENC INDUSTRIES (FR) 1979-04-03 US disclosed
US-4091032-A ANTIMICROBIAL AGENTS ABBOTT LABORATORIES (US) 1978-05-23 US disclosed
US-4088670-A P-(DIMETHYLVINYLSILYL-METHOXY)-BENZOYL CHLORIDE FROM DIMETHYLVINYL-CHLOROMETHYLSILANE AND A P-HYDROXYBENZOIC ACID RHONE-POULENC INDUSTRIES (FR) 1978-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392498-A1 POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS HNRNPC, RNASE1, NSUN3 APOBEC3G 234/4885TDP1 495/4885CYP4F2 4145/4885
US-11136326-B2 Pyrrolopyrimidine derivatives as TAM inhibitors FLT3, MERTK, MIF APOBEC3G 2279/4885TDP1 1156/4885CYP4F2 825/4885
US-20200239452-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 APOBEC3G 3611/4885TDP1 637/4885CYP4F2 847/4885
US-20200181151-A1 PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS FLT3, MERTK, MIF APOBEC3G 2279/4885TDP1 1156/4885CYP4F2 825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.