Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407032 | 0.82 | APLNR (0.43) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL1437011 | 0.79 | TDP1 (0.40) | APLNRTDP1CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL28622640 | 0.78 | TDP1 (0.39) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL5073789 | 0.76 | APLNR (0.44) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL284141 | 0.75 | APLNR (0.55) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL10087239 | 0.74 | APLNR (0.53) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL724429 | 0.74 | APLNR (0.38) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL759712 | 0.73 | APLNR (0.56) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL9079095 | 0.73 | TDP1 (0.51) | TDP1CA1CA2MAOAMAOB | |
| SCHEMBL4083189 | 0.72 | APLNR (0.42) | APLNRTDP1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753548-A | Fused heteroaromatic pyrrolidones as SYK inhibitors | TAKAEDA CHEMICAL IND LTD | 2012-10-24 | — | — | CN | disclosed |