Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 8/20 | 0.42 |
| ▸ | THRB | P10828 | 8/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522420 | 0.94 | GABRA1 (0.42) | TOP2ATOP2BTHRATHRBEGLN1 | |
| SCHEMBL522570 | 0.84 | MCL1 (0.46) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL523582 | 0.80 | THRA (0.49) | THRATHRBEGLN1EGLN2BBOX1 | |
| SCHEMBL523190 | 0.80 | EGLN1 (0.51) | TOP2ATOP2BTHRATHRBEGLN1 | |
| SCHEMBL523555 | 0.79 | ALDH1A1 (0.46) | GABRPGABRDALDH1A1MAPTGABRA1 | |
| SCHEMBL522588 | 0.78 | EGLN1 (0.53) | TOP2ATOP2BTHRATHRBEGLN1 | |
| SCHEMBL523204 | 0.77 | MCL1 (0.41) | TOP2ATOP2BTHRATHRBEGLN1 | |
| SCHEMBL15433916 | 0.76 | THRA (0.43) | THRATHRBEGLN1EGLN2BBOX1 | |
| SCHEMBL28488469 | 0.75 | EGLN1 (0.64) | THRATHRBEGLN1EGLN2BBOX1 | |
| SCHEMBL522739 | 0.75 | POLB (0.48) | EGLN1EGLN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102718708-A | Novel nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN INC | 2012-10-10 | — | — | CN | disclosed |