Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936428 | 0.83 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2MAPTRAB9A | |
| SCHEMBL936466 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4ESMN1; SMN2MAPTRAB9A | |
| SCHEMBL937188 | 0.79 | KMT2A (0.49) | ALDH1A1KDM4ESMN1; SMN2RAB9AADRB2 | |
| SCHEMBL936475 | 0.79 | KMT2A (0.49) | ALDH1A1KDM4ESMN1; SMN2RAB9AADRB2 | |
| SCHEMBL936476 | 0.79 | KMT2A (0.49) | ALDH1A1KDM4ESMN1; SMN2RAB9AADRB2 | |
| SCHEMBL937208 | 0.75 | ADRB3 (0.48) | ADRB2ADRB1CYP2D6HIF1A | |
| SCHEMBL10694902 | 0.74 | ALDH1A1 (0.62) | ALDH1A1KDM4ESMN1; SMN2MAPTRAB9A | |
| SCHEMBL936657 | 0.72 | MAOA (0.43) | ALDH1A1RAB9ABACE1KMT2AL3MBTL1 | |
| SCHEMBL10552506 | 0.72 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL1931817 | 0.72 | LMNA (0.58) | ALDH1A1KDM4ESMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102791269-A | PPAR-sparing thiazolidinediones and combinations for treating neurodegenerative diseases | METABOLIC SOLUTIONS DEV CO | 2012-11-21 | — | — | CN | disclosed |
| CN-102753170-A | Ppar-sparing thiazolidinediones and combinations for the treatment of diabetes mellitus and other metabolic diseases | METABOLIC SOLUTIONS DEV CO | 2012-10-24 | — | — | CN | disclosed |