Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.37 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.37 |
| ▸ | KAT7 | O95251 | 2/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791232 | 0.89 | ALDH1A1 (0.34) | CNR2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL7902418 | 0.85 | LMNA (0.42) | ALOX5APFEN1LMNAMEN1KMT2A | |
| SCHEMBL2789961 | 0.85 | ALOX5AP (0.40) | TRPV3ALOX5APFEN1SCN9ALMNA | |
| SCHEMBL7900706 | 0.83 | ALOX5AP (0.42) | TRPV3ALOX5APFEN1SCN9ALMNA | |
| SCHEMBL7892449 | 0.82 | CACNA1B (0.33) | TRPV3SCN9A | |
| SCHEMBL7898358 | 0.78 | KLK5 (0.30) | — | |
| SCHEMBL2792403 | 0.78 | PROKR1 (0.49) | CNR2SCN9AUSP30 | |
| SCHEMBL7901024 | 0.77 | ALOX5AP (0.41) | TRPV3ALOX5APFEN1SCN9ATP53 | |
| SCHEMBL2791259 | 0.77 | ALOX5AP (0.43) | TRPV3ALOX5APFEN1SCN9AKAT6A | |
| SCHEMBL2789780 | 0.76 | NMT1 (0.33) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |