Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900706 | 0.90 | ALOX5AP (0.42) | ALOX5APFEN1GPR119BRD4ACKR3 | |
| SCHEMBL7901020 | 0.81 | TRPV3 (0.41) | ALOX5APFEN1GPR119ACKR3TRPV3 | |
| SCHEMBL2791259 | 0.80 | ALOX5AP (0.43) | ALOX5APFEN1GPR119TRPV3USP30 | |
| SCHEMBL2789961 | 0.80 | ALOX5AP (0.40) | ALOX5APFEN1GPR119ACKR3TRPV3 | |
| SCHEMBL7902418 | 0.80 | LMNA (0.42) | ALOX5APFEN1BRD4ACKR3USP30 | |
| SCHEMBL2789214 | 0.79 | CNR2 (0.44) | ALOX5APFEN1GPR119ACKR3TRPV3 | |
| SCHEMBL2792403 | 0.78 | PROKR1 (0.49) | ACKR3USP30SCN9ABCHEHTR6 | |
| SCHEMBL2792273 | 0.77 | CNR2 (0.44) | ALOX5APFEN1ACKR3USP30SCN9A | |
| SCHEMBL2789308 | 0.77 | TRPV3 (0.40) | ALOX5APFEN1TRPV3USP30SCN9A | |
| SCHEMBL2789844 | 0.76 | SSTR4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |