Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901020 | 0.83 | TRPV3 (0.41) | HPGDSALOX5APFEN1USP30 | |
| SCHEMBL2791498 | 0.80 | PIK3CD (0.39) | HPGDSCYP2C9CCNKCDK12PRMT5 | |
| SCHEMBL2791374 | 0.80 | CCNK (0.43) | HPGDSCYP2C9CCNKCDK12CNR2 | |
| SCHEMBL2791496 | 0.80 | PIK3CD (0.39) | HPGDSCYP2C9CCNKCDK12PRMT5 | |
| SCHEMBL2789048 | 0.79 | PIK3CD (0.39) | HPGDSCYP2C9CCNKCDK12PRMT5 | |
| SCHEMBL2789050 | 0.79 | PIK3CD (0.39) | HPGDSCYP2C9CCNKCDK12PRMT5 | |
| SCHEMBL2789214 | 0.78 | CNR2 (0.44) | CCNKCDK12CNR2ALOX5APFEN1 | |
| SCHEMBL2791259 | 0.77 | ALOX5AP (0.43) | ALOX5APFEN1USP30JAK2JAK1 | |
| SCHEMBL741975 | 0.76 | KCNH2 (0.52) | HPGDS | |
| SCHEMBL741974 | 0.76 | KCNH2 (0.52) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |