Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 3/20 | 0.34 |
| ▸ | CPT2 | P23786 | 2/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789943 | 0.90 | AKT1 (0.36) | CTSCCNR2CPT1ACPT2 | |
| SCHEMBL2792397 | 0.88 | CNR2 (0.35) | CTSCCNR2 | |
| SCHEMBL742247 | 0.87 | MAPT (0.39) | PARP1DRD2DRD4HTR1AHTR2A | |
| SCHEMBL742248 | 0.87 | MAPT (0.39) | PARP1DRD2DRD4HTR1AHTR2A | |
| SCHEMBL2789230 | 0.86 | CNR2 (0.39) | CNR2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL2790507 | 0.83 | CNR2 (0.40) | CNR2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2791698 | 0.82 | PROKR1 (0.37) | CNR2ALDH1A1KMT2A | |
| SCHEMBL2791366 | 0.80 | CNR2 (0.36) | PARP1CNR2POLBKDM4EALDH1A1 | |
| SCHEMBL742029 | 0.80 | NSD2 (0.36) | CTSCDRD2DRD4 | |
| SCHEMBL742030 | 0.80 | NSD2 (0.36) | CTSCDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |