Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 12/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742030 | 1.00 | NSD2 (0.36) | NSD2PADI4DRD2DRD4DRD3 | |
| SCHEMBL741797 | 0.94 | LIPG (0.35) | NSD2PADI4DRD2DRD4DRD3 | |
| SCHEMBL741798 | 0.94 | LIPG (0.35) | NSD2PADI4DRD2DRD4DRD3 | |
| SCHEMBL741966 | 0.90 | AKT1 (0.36) | PADI4 | |
| SCHEMBL742052 | 0.90 | AKT1 (0.36) | PADI4 | |
| SCHEMBL741160 | 0.89 | BTK (0.31) | CTSC | |
| SCHEMBL741161 | 0.89 | BTK (0.31) | CTSC | |
| SCHEMBL742248 | 0.86 | MAPT (0.39) | DRD2DRD4DRD3RXFP1 | |
| SCHEMBL742247 | 0.86 | MAPT (0.39) | DRD2DRD4DRD3RXFP1 | |
| SCHEMBL739856 | 0.86 | PIK3CD (0.37) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |