Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.62 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13551428 | 0.88 | APP (0.72) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13551443 | 0.86 | APP (0.65) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL13387384 | 0.84 | APP (0.73) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL13387382 | 0.84 | APP (0.73) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13551425 | 0.83 | APP (0.71) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL18688715 | 0.82 | APP (0.57) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL18688714 | 0.82 | APP (0.57) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15910125 | 0.79 | APP (0.84) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12479735 | 0.79 | APP (0.62) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12479731 | 0.79 | APP (0.62) | APPPTGER4KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102743769-A | Imaging of Beta-amyloid peptide and inhibition of Beta-amyloid Peptide aggregation | UNIV HONG KONG BAPTIST | 2012-10-24 | — | — | CN | disclosed |