Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746496 | 0.74 | CYP2C19 (0.46) | KDM4EGAASMN1; SMN2MAPTHTT | |
| SCHEMBL27267881 | 0.71 | HRH4 (0.54) | HRH3KDM4EMAPTLRRK2ALDH1A1 | |
| SCHEMBL23921724 | 0.71 | SORD (0.55) | HRH3CHRNA7KDM4EGAASMN1; SMN2 | |
| SCHEMBL2233298 | 0.70 | LRRK2 (0.44) | HRH3CHRNA7KDM4EGAASMN1; SMN2 | |
| SCHEMBL2075530 | 0.70 | KIT (0.48) | HRH3KDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL25515015 | 0.67 | GAA (0.48) | HRH3CHRNA7KDM4EGAASMN1; SMN2 | |
| SCHEMBL2085443 | 0.67 | KIT (0.51) | HRH3LRRK2KITFLT3 | |
| SCHEMBL19922639 | 0.67 | HRH3 (0.45) | HRH3CHRNA7KDM4EGAASMN1; SMN2 | |
| SCHEMBL4202025 | 0.66 | HRH3 (0.39) | HRH3CHRNA7KDM4EGAASMN1; SMN2 | |
| SCHEMBL13472369 | 0.66 | KMO (0.62) | CHRNA7MAPTRAD52LRRK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102741256-A | Bicyclic heteroaryl derivatives having inhibitory activity for protein kinase | HANMI PHARM IND CO LTD | 2012-10-17 | — | — | CN | disclosed |