Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111262 | 0.78 | HRH4 (0.44) | CYP2C19KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL752497 | 0.74 | KDM4E (0.45) | HTTSMN1; SMN2KDM4EPIK3CBKMT2A | |
| SCHEMBL31110333 | 0.74 | CYP2C19 (0.68) | CYP2C19KMOHTTSMN1; SMN2KDM4E | |
| SCHEMBL27896130 | 0.74 | HRH3 (0.45) | CYP2C19HTTSMN1; SMN2KDM4EGAA | |
| SCHEMBL1110166 | 0.70 | CYP2C19 (0.42) | CYP2C19KMOHTTSMN1; SMN2KDM4E | |
| SCHEMBL455110 | 0.70 | PIK3CA (0.44) | CYP2C19KMOHTTSMN1; SMN2KDM4E | |
| SCHEMBL352791 | 0.69 | KMT2A (0.51) | HTTSMN1; SMN2KDM4EGAAKMT2A | |
| SCHEMBL459151 | 0.68 | SORD (0.51) | CYP2C19KMOHTTSMN1; SMN2KDM4E | |
| SCHEMBL29464006 | 0.68 | SORD (0.51) | CYP2C19KMOHTTSMN1; SMN2KDM4E | |
| SCHEMBL4466700 | 0.68 | LMNA (0.48) | HTTSMN1; SMN2KDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105669564-B | Carbamide compounds, its preparation method, pharmaceutical composition, intermediate and its application | 上海医药工业研究院 | 2018-05-04 | — | — | CN | disclosed |
| CN-105669564-A | Urea compound and preparation method, medicine composition, intermediate and application thereof | 上海医药工业研究院 | 2016-06-15 | — | — | CN | disclosed |
| CN-102958921-B | Urea compound, preparation method thereof, intermediate thereof and application thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-03-23 | — | — | CN | disclosed |
| EP-0232025-A2 | Dihydropyridine anti-ischaemic and antihypertensive agents | Pfizer Limited (GB) | 1987-08-12 | — | — | EP | disclosed |