Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Catechol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechol SCHEMBL28263540 | 0.86 | CA12 (0.43) | SMN1; SMN2CA12CA2CA14POLB | |
| Pyrogallol SCHEMBL1056082 | 0.85 | ALDH1A1 (0.57) | CA12CA2CA14ALDH1A1KDM4E | |
| Catechol SCHEMBL28455903 | 0.84 | CA12 (0.42) | SMN1; SMN2CA12CA2CA14POLB | |
| Catechol SCHEMBL11778548 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2CA12CA2CA14POLB | |
| Catechol SCHEMBL27989011 | 0.83 | KDM4E (0.67) | SMN1; SMN2CA12CA2CA14POLB | |
| Catechol SCHEMBL1143838 | 0.83 | KDM4E (0.67) | SMN1; SMN2CA12CA2CA14POLB | |
| Catechol SCHEMBL235068 | 0.83 | KDM4E (0.67) | SMN1; SMN2CA12CA2CA14POLB | |
| Catechol SCHEMBL29652083 | 0.83 | KDM4E (0.67) | SMN1; SMN2CA12CA2CA14POLB | |
| Phenol SCHEMBL28250922 | 0.82 | CA12 (0.55) | SMN1; SMN2CA12CA2CA14ALDH1A1 | |
| Pyrogallol SCHEMBL4255147 | 0.81 | CA1 (0.52) | CA12CA2CA14ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102958913-B | The method of the 5-halogenated phenols that preparation ortho position replaces and synthetic intermediate thereof | RHODIA (CHINA) CO.,LTD. (CN) | 2015-11-25 | — | — | CN | disclosed |
| CN-102958913-A | Process for preparing an ortho-substituted 5-halophenol and a synthesis intermediate thereof | RHODIA CHINA CO LTD | 2013-03-06 | — | — | CN | disclosed |