Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19233710 | 0.80 | ALKBH5 (0.50) | GPR3ALKBH5FTOTSHRKDM4E | |
| SCHEMBL19233707 | 0.79 | KDM4E (0.47) | GPR3ALKBH5FTOTSHRKDM4E | |
| SCHEMBL31132408 | 0.77 | GPR3 (0.61) | GPR3ALKBH5FTOTSHRKDM4E | |
| SCHEMBL483003 | 0.77 | GPR3 (0.61) | GPR3ALKBH5FTOTSHRKDM4E | |
| Bromide SCHEMBL15569971 | 0.76 | GPR3 (0.58) | GPR3ALKBH5FTOTSHRKDM4E | |
| Bromide SCHEMBL15569972 | 0.76 | GPR3 (0.58) | GPR3ALKBH5FTOTSHRKDM4E | |
| Iodide SCHEMBL344509 | 0.76 | GPR3 (0.58) | GPR3ALKBH5FTOTSHRKDM4E | |
| SCHEMBL8586710 | 0.75 | HTR2A (0.49) | GPR3ALKBH5FTOTSHRKDM4E | |
| SCHEMBL16381431 | 0.74 | GPR3 (0.56) | GPR3ALKBH5FTOTSHRKDM4E | |
| SCHEMBL8083530 | 0.74 | GPR3 (0.56) | GPR3ALKBH5FTOTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104203943-A | Substituted pyrimidine compounds and their use as SYK inhibitors | GENOSCO | 2014-12-10 | — | — | CN | claimed |
| CN-104203943-B | Substituted pyrimidine compound and its purposes as SYK inhibitor | 盖诺斯克公司 | 2017-12-29 | — | — | CN | disclosed |
| CN-103619835-B | Novel Pyrimidine Derivatives | Novija Research (SE) | 2016-11-30 | — | — | CN | disclosed |
| CN-104203943-A | Substituted pyrimidine compounds and their use as SYK inhibitors | GENOSCO | 2014-12-10 | — | — | CN | disclosed |
| CN-103003264-B | Novel pyrimidine derivatives | CHEMILIA AB | 2014-08-06 | — | — | CN | disclosed |
| CN-103619835-A | Novel pyrimidine derivatives | CHEMILIA AB | 2014-03-05 | — | — | CN | disclosed |
| CN-103003264-A | Novel pyrimidine derivatives | CHEMILIA AB | 2013-03-27 | — | — | CN | disclosed |