Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28665142 | 0.78 | IDO1 (0.44) | POLBKDM4ECYP3A4MAPTGAA | |
| SCHEMBL18602719 | 0.78 | CYP3A4 (0.48) | KDM4ECYP3A4MAPTSIGMAR1HPGD | |
| SCHEMBL11064796 | 0.77 | TDP1 (0.41) | POLBKDM4ECYP3A4MAPTGAA | |
| SCHEMBL11061936 | 0.77 | IDO1 (0.40) | POLBKDM4ECYP3A4MAPTGAA | |
| SCHEMBL13616530 | 0.76 | CES2 (0.38) | MAPTSIGMAR1GAAMEN1KMT2A | |
| SCHEMBL19785138 | 0.74 | MEN1 (0.42) | KDM4ECYP3A4MAPTSIGMAR1GAA | |
| SCHEMBL17104769 | 0.73 | TP53 (0.39) | EPHX2SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL779932 | 0.72 | CES2 (0.37) | SIGMAR1SMN1; SMN2TDP1TP53TSHR | |
| SCHEMBL9760714 | 0.72 | CES2 (0.37) | SIGMAR1SMN1; SMN2TDP1TP53TSHR | |
| SCHEMBL30828004 | 0.72 | CES2 (0.37) | SIGMAR1SMN1; SMN2TDP1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103030656-B | The synthetic method of proteasome inhibitor bortezomib and analogue thereof | PEKING UNIVERSITY (CN) | 2015-08-26 | — | — | CN | disclosed |
| CN-103030656-A | Synthetic method of proteasome inhibitor bortezomib and analogs | UNIV BEIJING | 2013-04-10 | — | — | CN | disclosed |