Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | SORD | Q00796 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558132 | 0.78 | SORD (0.55) | GPR119GSK3BCYP2D6SORDHRH4 | |
| SCHEMBL13703145 | 0.76 | GRM1 (0.47) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL26701022 | 0.76 | GRM1 (0.47) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL30775215 | 0.73 | GPR119 (0.47) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL18867080 | 0.73 | L3MBTL3 (0.53) | ACVR1 | |
| SCHEMBL23875356 | 0.73 | GPR119 (0.44) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL30775219 | 0.73 | GPR119 (0.47) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL24929586 | 0.73 | GPR119 (0.47) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL674099 | 0.73 | HRH4 (0.54) | GPR119GRM1KCNH2JAK2JAK1 | |
| SCHEMBL24742884 | 0.73 | SORD (0.50) | GSK3BCYP2D6SORDHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101341134-B | Pyrimidine derivatives | PFIZER LTD | 2013-05-01 | — | — | CN | disclosed |