Sugi Predict

Sugi Predict / Compounds / SCHEMBL279049

SCHEMBL279049

SCHEMBL279049

O=[N+]([O-])c1cc(CO)ccc1Br

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.50
▸ MAPT P10636 5/20 0.50
▸ CYP2D6 P10635 1/20 0.50
▸ POLB P06746 1/20 0.45
▸ TTR P02766 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ ABL1 P00519 3/20 0.40
▸ BCR P11274 3/20 0.40
▸ SNCA P37840 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ MAPK1 P28482 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1242085 0.86 TSHR (0.53) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL15248984 0.85 ALDH1A1 (0.47) ALDH1A1MAPTCYP2D6POLBTTR
SCHEMBL672403 0.85 ALDH1A1 (0.49) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL9138875 0.85 ALDH1A1 (0.49) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL29519283 0.85 ALDH1A1 (0.49) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL30385788 0.83 ALDH1A1 (0.47) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL3073523 0.83 ALDH1A1 (0.47) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL515466 0.82 MAPT (0.54) ALDH1A1MAPTPOLBTTRSMN1; SMN2
SCHEMBL278730 0.81 ALDH1A1 (0.50) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2
SCHEMBL15286114 0.81 ALDH1A1 (0.46) ALDH1A1MAPTCYP2D6POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250275968-A1 INHIBITORS OF TAU PROTEINS DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E.V. (DE) 2025-09-04 — — US disclosed
EP-4518858-A1 INHIBITORS OF TAU PROTEINS Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DE) 2025-03-12 — — EP disclosed
CN-119562809-A Inhibitors of tau protein 德国神经退行性疾病研究中心 2025-03-04 — — CN disclosed
WO-2023213850-A1 INHIBITORS OF TAU PROTEINS DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E. V. (DZNE) (DE) 2023-11-09 — — WO disclosed
EP-3330263-B1 PHENYLUREA DERIVATIVES AS ISOCITRATE DEHYDROGENASE 2 INHIBITORS FOR TREATING CANCER CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2020-11-18 — — EP disclosed
CN-107922375-B Anti-tumor compounds targeting the IDH2 mutation and methods of use thereof 正大天晴药业集团股份有限公司 2020-05-22 — — CN disclosed
US-10155722-B2 Antitumor compound targeting IDH2 mutation and method of use thereof CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2018-12-18 — — US disclosed
US-20180222853-A1 ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2018-08-09 — — US disclosed
US-20180222853-A1 ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2018-08-09 — — US disclosed
EP-3330263-A1 ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) 2018-06-06 — — EP disclosed
CN-101384592-A Antiviral compounds ABBOTT LAB (US) 2009-03-11 — — CN disclosed
EP-1979349-A2 ANTI-VIRAL COMPOUNDS Abbott Laboratories (US) 2008-10-15 — — EP disclosed
WO-2008012470-A2 SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES GENFIT (FR) 2008-01-31 — — WO disclosed
US-20070232645-A1 ANTI-VIRAL COMPOUNDS ABBVIE INC. 2007-10-04 — — US disclosed
US-20070176163-A1 2,7-Carbazolenevinylene derivatives as novel materials in producing organic based electronic devices NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2007-08-02 — — US disclosed
US-20070176163-A1 2,7-Carbazolenevinylene derivatives as novel materials in producing organic based electronic devices NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2007-08-02 — — US disclosed
WO-2007076035-A2 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2007-07-05 — — WO disclosed
US-20070069197-A1 Monomers, oligomers and polymers of 2-functionalized and 2,7-difunctionalized carbzoles UNIVERSITE LAVAL (CA) 2007-03-29 — — US disclosed
EP-1660450-A1 MONOMERS, OLIGOMERS AND POLYMERS OF 2-FUNCTIONALIZED AND 2,7-DIFUNCTIONALIZED CARBAZOLES Université Laval (CA) 2006-05-31 — — EP disclosed
WO-2005016882-A1 MONOMERS, OLIGOMERS AND POLYMERS OF 2-FUNCTIONALIZED AND 2,7-DIFUNCTIONALIZED CARBAZOLES UNIVERSITE LAVAL (CA) 2005-02-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10155722-B2 Antitumor compound targeting IDH2 mutation and method of use thereof IDH2, IDH3A, IDH1 ALDH1A1 310/4885MAPT 3977/4885CYP2D6 2385/4885
US-20250275968-A1 INHIBITORS OF TAU PROTEINS MAPT, PSEN2, PSEN1 ALDH1A1 4322/4885MAPT 1/4885CYP2D6 4821/4885
US-20070069197-A1 Monomers, oligomers and polymers of 2-functionalized and 2,7-difunctionalized carbzoles TELO2, DNMT1, DDT ALDH1A1 2329/4885MAPT 3171/4885CYP2D6 1962/4885
US-20070232645-A1 ANTI-VIRAL COMPOUNDS HAVCR2, MAVS, EIF2AK2 ALDH1A1 2723/4885MAPT 1347/4885CYP2D6 783/4885
US-20180222853-A1 ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF IDH2, IDH3A, IDH1 ALDH1A1 310/4885MAPT 3977/4885CYP2D6 2385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.