Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581720 | 0.94 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2581719 | 0.94 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2581799 | 0.94 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2791239 | 0.90 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2795056 | 0.89 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2790399 | 0.88 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2795422 | 0.88 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL21901978 | 0.86 | P2RX7 (0.85) | P2RX7 | |
| SCHEMBL13229606 | 0.86 | P2RX7 (0.75) | P2RX7 | |
| SCHEMBL2578259 | 0.84 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168171-A1 | Piperidinone Carboxamide Derivatives as P2X7 Modulators | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | US | claimed |
| US-20100168171-A1 | Piperidinone Carboxamide Derivatives as P2X7 Modulators | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | US | disclosed |
| US-20100168171-A1 | Piperidinone Carboxamide Derivatives as P2X7 Modulators | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | US | disclosed |
| US-20100168171-A1 | Piperidinone Carboxamide Derivatives as P2X7 Modulators | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | US | disclosed |
| WO-2008116845-A1 | PIPERIDINONE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168171-A1 | Piperidinone Carboxamide Derivatives as P2X7 Modulators | P2RX7, P2RX3, P2RX5 | P2RX7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.