Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 8/20 | 0.39 |
| ▸ | VEGFA | P15692 | 4/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279190 | 0.80 | CCR5 (0.43) | CCR5HPGDTSHR | |
| SCHEMBL279202 | 0.79 | HPGD (0.36) | CCR5HPGDTSHR | |
| SCHEMBL279339 | 0.79 | LMNA (0.40) | CCR5HPGDTSHR | |
| SCHEMBL275612 | 0.76 | TBXA2R (0.38) | ARPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL278967 | 0.76 | TBXA2R (0.38) | ARPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL279350 | 0.76 | TBXA2R (0.36) | CCR5ARHPGDTSHRCYP19A1 | |
| SCHEMBL279205 | 0.76 | TBXA2R (0.36) | ARPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL279344 | 0.76 | SLC6A4 (0.46) | HPGDTSHRSLC6A4 | |
| SCHEMBL278988 | 0.75 | CCR5 (0.45) | CCR5HPGD | |
| SCHEMBL276480 | 0.74 | EPAS1 (0.49) | CCR5EPAS1VEGFAARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156610-A1 | Spiroindolinone Derivatives | SDHA, AR, XPOT | CCR5 2331/4885EPAS1 2981/4885VEGFA 2013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.