Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 15/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323718 | 0.83 | PDE2A (0.51) | PDE2APDE10AGABRB3 | |
| SCHEMBL2791778 | 0.78 | PDE2A (0.53) | PDE2APDE10AGABRB3GABRPGABRD | |
| SCHEMBL7808426 | 0.75 | PDE10A (1.00) | PDE2APDE10APDE7A | |
| SCHEMBL968965 | 0.70 | PDE10A (0.55) | PDE2APDE10A | |
| SCHEMBL7914751 | 0.69 | PDE2A (0.51) | PDE2APDE10A | |
| SCHEMBL3326270 | 0.68 | PDE2A (0.64) | PDE2APDE10A | |
| SCHEMBL3323059 | 0.67 | PDE2A (0.62) | PDE2APDE10A | |
| SCHEMBL971266 | 0.64 | PDE2A (0.56) | PDE2APDE10APDE7A | |
| SCHEMBL23690320 | 0.63 | PDE2A (0.38) | PDE2APDE10AGABRB3GABRPGABRD | |
| SCHEMBL7812114 | 0.63 | PDE2A (0.38) | PDE2APDE10AGABRB3GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |