Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KIF20B | Q96Q89 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325917 | 0.79 | PDE2A (0.42) | PDE2APDE10AGABRB3MKNK1MKNK2 | |
| SCHEMBL2791202 | 0.78 | PDE2A (0.60) | PDE2APDE10AGABRB3GABRA2GABRB2 | |
| SCHEMBL7808426 | 0.70 | PDE10A (1.00) | PDE2APDE10A | |
| SCHEMBL3662318 | 0.68 | PDE10A (0.43) | PDE2APDE10ALCK | |
| SCHEMBL3323718 | 0.66 | PDE2A (0.51) | PDE2APDE10AGABRB3 | |
| SCHEMBL7812114 | 0.65 | PDE2A (0.38) | PDE2APDE10AGABRB3KIF20BGABRA2 | |
| SCHEMBL7914751 | 0.63 | PDE2A (0.51) | PDE2APDE10A | |
| SCHEMBL166766 | 0.62 | ALDH1A1 (0.53) | — | |
| SCHEMBL8321562 | 0.62 | PDE2A (0.44) | PDE2AGABRB3GABRA2GABRB2GABRP | |
| SCHEMBL23690320 | 0.62 | PDE2A (0.38) | PDE2APDE10AGABRB3KIF20BGABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |