Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 13/20 | 0.37 |
| ▸ | BTK | Q06187 | 11/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27930638 | 0.86 | JAK3 (0.38) | JAK3BTKKDM4ELRRK2 | |
| SCHEMBL27912568 | 0.82 | MMP2 (0.38) | PAK4IRAK4JAK3BTK | |
| SCHEMBL1068268 | 0.78 | SYK (0.50) | PAK4IRAK4JAK3BTK | |
| SCHEMBL12085438 | 0.74 | SYK (0.57) | PAK4IRAK4JAK3BTK | |
| SCHEMBL1018471 | 0.70 | IRAK4 (0.55) | PAK4IRAK4JAK3BTK | |
| SCHEMBL12085463 | 0.68 | CCNT1 (0.59) | PAK4IRAK4JAK3BTK | |
| SCHEMBL14666824 | 0.68 | PAK4 (0.55) | PAK4IRAK4JAK3BTK | |
| SCHEMBL12085425 | 0.67 | MERTK (0.66) | PAK4IRAK4JAK3BTKLRRK2 | |
| SCHEMBL12085309 | 0.66 | IRAK4 (0.59) | PAK4IRAK4JAK3BTK | |
| SCHEMBL14666821 | 0.66 | SYK (0.54) | PAK4IRAK4JAK3BTKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103224497-A | Inhibitors of protein kinases | PORTOLA PHARM INC | 2013-07-31 | — | — | CN | disclosed |