Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.38 |
| ▸ | BTK | Q06187 | 9/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27912569 | 0.86 | PAK4 (0.39) | JAK3BTKLRRK2KDM4E | |
| SCHEMBL27912568 | 0.82 | MMP2 (0.38) | JAK3BTKAXLTYRO3MERTK | |
| SCHEMBL25305775 | 0.65 | L3MBTL1 (0.60) | ADAMTS4MMP1MMP2MMP13MMP14 | |
| SCHEMBL14547700 | 0.64 | PAK4 (0.53) | JAK3BTKMERTKLRRK2RAB9A | |
| SCHEMBL12085463 | 0.63 | CCNT1 (0.59) | JAK3BTKMERTKSYK | |
| SCHEMBL17262818 | 0.62 | JAK3 (0.56) | JAK3BTKMERTK | |
| SCHEMBL12085409 | 0.60 | JAK3 (0.57) | JAK3BTKSYK | |
| SCHEMBL11113546 | 0.59 | KEAP1 (0.52) | ADAMTS4MMP1MMP2MMP13MMP14 | |
| SCHEMBL12085351 | 0.57 | PAK4 (0.58) | JAK3BTKPTK2SYK | |
| SCHEMBL12085310 | 0.57 | JAK3 (0.55) | JAK3BTKTYRO3MERTKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103224497-A | Inhibitors of protein kinases | PORTOLA PHARM INC | 2013-07-31 | — | — | CN | disclosed |