Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.61 |
| ▸ | TDO2 | P48775 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.45 |
| ▸ | TUBB | P07437 | 2/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884271 | 0.82 | ESR1 (0.55) | CNR1KDM4ECYP19A1ALDH1A1MEN1 | |
| SCHEMBL27957069 | 0.80 | CYP11B1 (0.67) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| SCHEMBL1605900 | 0.78 | CYP11B1 (0.43) | CYP11B1CYP11B2TDO2IDO1KDM4E | |
| SCHEMBL2792363 | 0.76 | CYP11B2 (1.00) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| Hydrochloric Acid SCHEMBL1604935 | 0.75 | CYP11B2 (0.97) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| SCHEMBL1605030 | 0.73 | CYP11B1 (0.66) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| SCHEMBL1606265 | 0.73 | CYP11B2 (0.61) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| SCHEMBL29954680 | 0.73 | CYP11B1 (0.61) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| SCHEMBL7808349 | 0.73 | CYP11B1 (0.61) | CYP11B1CYP11B2TDO2IDO1LRRK2 | |
| SCHEMBL28898943 | 0.72 | TUBB4A (0.66) | CYP11B1CYP11B2TDO2IDO1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |