SCHEMBL27921963

SCHEMBL27921963

[CH2]CCC(c1ccccc1N)N1CCCC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.38
CYP2C19 P33261 6/20 0.38
CYP3A4 P08684 5/20 0.38
CYP2D6 P10635 5/20 0.38
TSHR P16473 2/20 0.38
SLC6A2 P23975 3/20 0.37
SLC6A3 Q01959 3/20 0.37
SLC6A4 P31645 2/20 0.37
KEAP1 Q14145 1/20 0.36
DPP4 P27487 1/20 0.35
CYP2C9 P11712 5/20 0.34
KCNA5 P22460 4/20 0.34
KCNH2 Q12809 4/20 0.34
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.34
KCNE1 P15382 1/20 0.33
RAB9A P51151 1/20 0.33
MEN1 O00255 2/20 0.33
ALDH1A1 P00352 2/20 0.33
KMT2A Q03164 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8797214 0.75 CYP1A2 (0.40) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL6604030 0.75 CYP1A2 (0.62) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL28020315 0.68 MEN1 (0.36) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL21590184 0.68 MC4R (0.50) CYP2D6SLC6A3KCNH2
Hydrochloric Acid SCHEMBL4811226 0.67 KEAP1 (0.38) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL12513459 0.65 MC4R (0.52) CYP2D6TSHRSLC6A2SLC6A3SLC6A4
SCHEMBL8278787 0.65 DPP4 (0.73) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL3470666 0.65 DPP4 (0.73) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL3472246 0.63 DPP4 (0.50) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL9625233 0.62 L3MBTL1 (0.54) CYP2D6TSHRSLC6A2MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103354809-A Arylurea compound, intermediate and use thereof SHANGHAI INST PHARM INDUSTRY 2013-10-16 CN disclosed