Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 9/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 9/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15111297 | 0.79 | NSD2 (0.64) | DAOGPR84SCN9ASCN8ASCN10A | |
| SCHEMBL2092054 | 0.78 | SLC6A4 (0.56) | DAOGPR84SLC6A4CHRM5MPO | |
| SCHEMBL3989724 | 0.73 | ABL1 (0.54) | DAOGPR84NSD2ABL1PPARG | |
| SCHEMBL508197 | 0.73 | SLC6A4 (0.49) | DAOSLC6A4MPOL3MBTL1 | |
| SCHEMBL22621116 | 0.73 | SLC6A4 (0.51) | SLC6A4MPO | |
| SCHEMBL7929139 | 0.71 | SLC6A4 (0.50) | DAOSLC6A4MPOL3MBTL1 | |
| SCHEMBL16770891 | 0.71 | SLC6A4 (0.58) | SLC6A4 | |
| SCHEMBL22348782 | 0.70 | CYP11B1 (0.47) | — | |
| SCHEMBL9607433 | 0.70 | ALDH1A1 (0.49) | DAOGPR84SLC6A4 | |
| SCHEMBL9607326 | 0.70 | MAOA (0.44) | DAOGPR84SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103342695-B | 1',3'-disubstituted-4-pheny-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2'-ones | ORTHO MCNEIL JANSSEN PHARM | 2015-04-22 | — | — | CN | disclosed |
| CN-101801951-B | 1 ', 3 ' -disubstituted-4-phenyl-3, 4,5, 6-tetrahydro-2H, 1 ' H- [1,4 ' ] bipyridinyl-2 ' -ones | ORTHO MCNEIL JANSSEN PHARM | 2013-11-13 | — | — | CN | disclosed |