SCHEMBL27924945

SCHEMBL27924945

Cc1ncc(Cc2c[nH]cnc2=O)cn1

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9904933 0.83 CYP1A2 (0.34) PLA2G7
SCHEMBL27924946 0.83 PLA2G7 (0.44) PLA2G7
SCHEMBL9904824 0.81 PLA2G7 (0.39) PLA2G7
SCHEMBL9905012 0.76 PARG (0.36) PLA2G7
SCHEMBL9259240 0.73 HRH3 (0.40)
SCHEMBL9106375 0.71 ADORA2A (0.34) PLA2G7
SCHEMBL9381117 0.67 CYP3A4 (0.34)
SCHEMBL312269 0.65
SCHEMBL15262284 0.64 PLA2G7 (0.36) PLA2G7
SCHEMBL13851861 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103347864-A For treating diseases caused by Lp-PLA2Pyrimidone compounds for mediated diseases or conditions GLAXO GROUP LTD 2013-10-09 CN disclosed