Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27924946 | 0.76 | PLA2G7 (0.44) | TSHR | |
| SCHEMBL9904824 | 0.75 | PLA2G7 (0.39) | — | |
| SCHEMBL27924945 | 0.73 | PLA2G7 (0.31) | — | |
| SCHEMBL9904933 | 0.70 | CYP1A2 (0.34) | LMNATSHRALDH1A1 | |
| SCHEMBL9905012 | 0.70 | PARG (0.36) | ALDH1A1 | |
| SCHEMBL30783235 | 0.69 | DAO (0.48) | LMNA | |
| SCHEMBL9259245 | 0.67 | HRH3 (0.60) | HRH3PDE3BPDE3AHTR1D | |
| SCHEMBL3334615 | 0.63 | CYP2A6 (0.57) | HRH3HTR1DEPHX2TSHRALDH1A1 | |
| SCHEMBL30330993 | 0.63 | CYP2A6 (0.57) | HRH3HTR1DEPHX2TSHRALDH1A1 | |
| SCHEMBL9381117 | 0.63 | CYP3A4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6009625-A | — | — | None | — | — | JP | disclosed |
| US-5430149-A | 5-[(4-bromophenyl)methyl]4-pyrimidinones | SYNTHELABO (FR) | 1995-07-04 | — | — | US | disclosed |
| US-5430149-A | 5-[(4-bromophenyl)methyl]4-pyrimidinones | SYNTHELABO (FR) | 1995-07-04 | — | — | US | disclosed |
| US-5312920-A | Process for preparing 4-pyrimidinones | SYNTHELABO (FR) | 1994-05-17 | — | — | US | disclosed |
| JP-H069625-A | NEW PRODUCTION OF 4-PYRIMIDINONES | SYNTHELABO SA | 1994-01-18 | — | — | JP | disclosed |