Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26666190 | 0.82 | GSR (0.40) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29008892 | 0.80 | GSR (0.48) | LMNAALOX15BLMKMT2A | |
| SCHEMBL16290200 | 0.80 | CA2 (0.47) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL302961 | 0.78 | GSR (0.47) | LMNAALOX15KMT2A | |
| SCHEMBL11472654 | 0.78 | GSR (0.47) | LMNAALOX15KMT2A | |
| SCHEMBL28176797 | 0.77 | LMNA (0.33) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL27413544 | 0.77 | GRIK1 (0.49) | MAPT | |
| SCHEMBL1010771 | 0.76 | — | — | |
| SCHEMBL28522874 | 0.76 | MAPT (0.33) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL27703023 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103421846-B | The application in gene therapy of the polymine of diurethane crosslinking | 中国科学院上海生命科学研究院 | 2016-06-22 | — | — | CN | claimed |
| CN-103421846-B | The application in gene therapy of the polymine of diurethane crosslinking | 中国科学院上海生命科学研究院 | 2016-06-22 | — | — | CN | disclosed |
| CN-103421846-A | Applications of diamino carbamate cross-linked polyethyleneimine in gene therapy | SHANGHAI INST BIOL SCIENCES | 2013-12-04 | — | — | CN | disclosed |