Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | XPO1 | O14980 | 2/20 | 0.82 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.82 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.82 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Osthole SCHEMBL17513161 | 0.91 | PTGS2 (1.00) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL50436 | 0.91 | PTGS2 (1.00) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL29595542 | 0.91 | PTGS2 (1.00) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL27950752 | 0.89 | PTGS2 (0.97) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL27681201 | 0.89 | PTGS2 (0.97) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL21683499 | 0.89 | PTGS2 (0.71) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL27803504 | 0.87 | PTGS2 (0.92) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL27659943 | 0.86 | PTGS2 (0.90) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| Osthole SCHEMBL28851790 | 0.82 | PTGS2 (0.82) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 | |
| SCHEMBL50304 | 0.80 | PTGS2 (0.79) | PTGS2ALDH1A1XPO1ABCB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168225-A1 | Small-Molecule Hepatitis C Virus (HCV) NS3/4A Serine Protease Inhibitors | JEAN FRANCOIS | 2010-07-01 | — | — | US | disclosed |
| WO-2008128344-A1 | SMALL-MOLECULE HEPATITIS C VIRUS (HCV) NS3/4A SERINE PROTEASE INHIBITORS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168225-A1 | Small-Molecule Hepatitis C Virus (HCV) NS3/4A Serine Protease Inhibitors | SRR, HAVCR2, CBR3 | PTGS2 511/4885ALDH1A1 1864/4885XPO1 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.