Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.56 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817650 | 0.87 | ROCK2 (0.58) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2792148 | 0.87 | ROCK2 (0.58) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL3504202 | 0.84 | ROCK2 (0.58) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2792274 | 0.83 | ROCK2 (0.54) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2790925 | 0.82 | RAB9A (0.56) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2794103 | 0.82 | ROCK2 (0.57) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2790576 | 0.82 | RAB9A (0.54) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2790680 | 0.82 | ROCK2 (0.64) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2792776 | 0.81 | ROCK2 (0.57) | ROCK2ROCK1NAMPTKDM4EL3MBTL1 | |
| SCHEMBL2792960 | 0.81 | NAMPT (0.53) | ROCK2ROCK1NAMPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2010-07-01 | — | — | US | disclosed |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | ROCK2 528/4885ROCK1 414/4885NAMPT 1420/4885 |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | ROCK2 528/4885ROCK1 414/4885NAMPT 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.