Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509445 | 0.81 | MAPT (0.39) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL16959210 | 0.81 | NOTUM (0.37) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL17711265 | 0.81 | MAPT (0.39) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL16950326 | 0.81 | ADRB2 (0.40) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL16961809 | 0.80 | NOTUM (0.36) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL17719392 | 0.79 | MAPT (0.37) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL15532524 | 0.77 | MAPT (0.46) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL1104689 | 0.77 | NOTUM (0.39) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL28797544 | 0.76 | P2RX7 (0.40) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL20515829 | 0.76 | NOTUM (0.38) | MAPTMEN1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261198-A | 2-arylimidazo[1,2-]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives | JIANGSU HENGRUI MEDICINE CO | 2013-08-21 | — | — | CN | claimed |
| CN-103261198-A | 2-arylimidazo[1,2-]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives | JIANGSU HENGRUI MEDICINE CO | 2013-08-21 | — | — | CN | disclosed |