Quinoline

Quinoline

SCHEMBL27933335

CCCCCCn1ccc2cc(O)c(O)cc21.c1ccc2ncccc2c1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 3/20 0.43
CCND1 P24385 3/20 0.43
CNR1 P21554 1/20 0.39
CNR2 P34972 1/20 0.39
ALDH1A1 P00352 2/20 0.39
TLR8 Q9NR97 3/20 0.38
LNPEP Q9UIQ6 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
SAE1 Q9UBE0 1/20 0.38
UBA2 Q9UBT2 1/20 0.38
SLC9A1 P19634 2/20 0.37
GLO1 Q04760 1/20 0.36
P2RX7 Q99572 1/20 0.36
HTT P42858 2/20 0.36
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL27735419 0.95 ALDH1A1 (0.41) CDK4CCND1CNR1CNR2ALDH1A1
Quinoline SCHEMBL27735431 0.86 ALDH1A1 (0.45) ALDH1A1KDM4ELMNAMAPTSMN1; SMN2
SCHEMBL1881998 0.84 CDK4 (0.46) CDK4CCND1ALDH1A1TLR8LNPEP
Quinoline SCHEMBL27609158 0.79 ALDH1A1 (0.49) ALDH1A1KDM4EMAPT
SCHEMBL29915749 0.78 ALDH1A1 (0.43) CDK4CCND1ALDH1A1LNPEPNPSR1
SCHEMBL111621 0.78 ALDH1A1 (0.43) CDK4CCND1ALDH1A1LNPEPNPSR1
Quinoline SCHEMBL28089463 0.76 ALDH1A1 (0.59) CNR1CNR2ALDH1A1TLR8SLC9A1
Dodecane SCHEMBL28937946 0.75 ALDH1A1 (0.68) ALDH1A1TLR8HTTKDM4ELMNA
Decane SCHEMBL9763188 0.75 ALDH1A1 (0.68) ALDH1A1TLR8HTTKDM4ELMNA
Quinoline SCHEMBL27987363 0.75 ALDH1A1 (0.68) ALDH1A1TLR8HTTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103517703-B Stain and application thereof 天野酶制品株式会社 2016-11-09 CN claimed
CN-103998016-B Employ the dyeing of the keratin fiber of indole analog AMANO ENZYME INC. (JP) 2015-09-16 CN claimed
CN-103517703-B Stain and application thereof 天野酶制品株式会社 2016-11-09 CN disclosed
CN-103998016-B Employ the dyeing of the keratin fiber of indole analog AMANO ENZYME INC. (JP) 2015-09-16 CN disclosed
CN-103998016-A Dye for keratin fibers using indole analogue AMANO ENZYME INC 2014-08-20 CN disclosed
CN-103517703-A Dyeing agent and use for same AMANO ENZYME INC 2014-01-15 CN disclosed