Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16598147 | 0.77 | HPGD (0.61) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL1722407 | 0.77 | KDM4E (0.70) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL12907922 | 0.77 | KDM4E (0.70) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL27815171 | 0.77 | KDM4E (0.70) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL31026221 | 0.77 | EGLN2 (0.68) | EGLN2FTOALDH1A1KMT2AHTT | |
| SCHEMBL15327067 | 0.76 | KDM4E (0.59) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL2201945 | 0.76 | EGLN1 (0.66) | KDM4EHPGDALDH1A1HSD17B10POLB | |
| SCHEMBL27949742 | 0.75 | ALDH1A1 (0.62) | KDM4EEGLN2FTOHPGDALDH1A1 | |
| SCHEMBL30927143 | 0.75 | ALDH1A1 (0.62) | KDM4EEGLN2FTOHPGDALDH1A1 | |
| SCHEMBL24405087 | 0.75 | FTO (0.65) | KDM4EEGLN2FTOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103539731-B | Amides compound of pyridine 2 and preparation method thereof, its pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2018-01-05 | — | — | CN | disclosed |
| CN-103539731-A | Pyridine-2-amide compound as well as preparation method, pharmaceutical composition and use thereof | SHANGHAI INST MATERIA MEDICA | 2014-01-29 | — | — | CN | disclosed |