Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 12/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561183 | 0.92 | IRAK4 (0.42) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4562331 | 0.90 | JAK2 (0.49) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL27935913 | 0.85 | JAK2 (0.49) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4560571 | 0.84 | JAK3 (0.42) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4561892 | 0.82 | JAK2 (0.51) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4561206 | 0.81 | JAK2 (0.45) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL5021903 | 0.80 | ALDH1A1 (0.45) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4559900 | 0.80 | JAK3 (0.45) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4562761 | 0.79 | JAK3 (0.44) | JAK3PTK2JAK2JAK1TYK2 | |
| SCHEMBL4561765 | 0.79 | CCNB2 (0.53) | JAK3JAK2JAK1TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |