Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936774 | 0.85 | NR1H4 (0.52) | NR1H4GPBAR1L3MBTL1AKR1B1 | |
| SCHEMBL21752829 | 0.84 | GPBAR1 (0.49) | NR1H4GPBAR1L3MBTL1GABRA5NTRK1 | |
| SCHEMBL28807438 | 0.83 | GABRA5 (0.51) | GPBAR1GABRA5P2RX7CYP2C19KDM4E | |
| SCHEMBL28805574 | 0.81 | NR1H4 (0.57) | NR1H4NTRK1 | |
| SCHEMBL12544227 | 0.80 | GPBAR1 (0.63) | GPBAR1L3MBTL1NTRK1MAPTCYP2C19 | |
| SCHEMBL27936756 | 0.80 | CYP2C19 (0.60) | NR1H4GPBAR1L3MBTL1MAPTCYP2C19 | |
| SCHEMBL30395460 | 0.80 | GPBAR1 (0.63) | GPBAR1L3MBTL1NTRK1MAPTCYP2C19 | |
| SCHEMBL27495332 | 0.78 | ALDH1A1 (0.59) | GABRA5MAPTKDM4E | |
| SCHEMBL19033 | 0.76 | HSD17B10 (0.65) | GPBAR1L3MBTL1KDM4E | |
| SCHEMBL27936782 | 0.75 | GPBAR1 (0.53) | GPBAR1GABRA5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103313982-B | Phenyl-isoxazole derivatives and process for the preparation thereof | IL-YANG PHARM. CO.,LTD. (KR) | 2016-02-03 | — | — | CN | disclosed |
| CN-103313982-A | Phenyl-isoxazole derivatives and process for the preparation thereof | IL YANG PHARM CO LTD | 2013-09-18 | — | — | CN | disclosed |