Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.60 |
| ▸ | NCF1 | P14598 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22775885 | 0.82 | PTK2 (0.58) | PTK2NCF1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28081340 | 0.78 | NCF1 (0.46) | PTK2NCF1L3MBTL1MEN1KMT2A | |
| SCHEMBL4268344 | 0.77 | NCF1 (0.62) | PTK2NCF1L3MBTL1LMNANOS2 | |
| SCHEMBL14980561 | 0.76 | PTK2 (1.00) | PTK2NCF1L3MBTL1MEN1KMT2A | |
| SCHEMBL13701721 | 0.76 | NCF1 (0.60) | PTK2NCF1MEN1KMT2ASLC6A2 | |
| SCHEMBL7420908 | 0.75 | GBA1 (0.61) | PTK2NCF1MAPK1GBA1NPC1 | |
| SCHEMBL12014904 | 0.73 | NCF1 (0.68) | PTK2NCF1MEN1KMT2AKDM4E | |
| SCHEMBL1591908 | 0.73 | NCF1 (0.52) | PTK2NCF1L3MBTL1MEN1KMT2A | |
| SCHEMBL14211037 | 0.73 | CYP2C19 (0.46) | PTK2L3MBTL1KMT2ASMN1; SMN2OPRK1 | |
| SCHEMBL27980157 | 0.73 | HDAC1 (0.68) | L3MBTL1MEN1KMT2ASMN1; SMN2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103391938-B | Pyrido [2,3-B] pyrazines derivatives and therepic use thereof | MERCK PATENT GMBH (DE) | 2016-02-24 | — | — | CN | disclosed |
| CN-103391938-A | Pyrido [2, 3 - b] pyrazine derivatives and their therapeutical uses | MERCK PATENT GMBH | 2013-11-13 | — | — | CN | disclosed |